α-ketoglutarate (α-KG)
2-Oxoglutarate (2-OG)
Molecular Formula ：C5H6O5
Molecular Weight：146.02
CAS No：328-50-7
Structure:
Brief introduction
α-Ketoglutarate (α-KG) is an important organic acid belonging to the class of keto acids. It is widely present in animal and plant cells, particularly in tissues with high energy demands, such as muscles, liver, and brain. It is a key intermediate in the tricarboxylic acid (TCA) cycle, also known as the citric acid cycle or Krebs cycle. α-KG plays a central role in cellular energy metabolism, amino acid synthesis, and nitrogen metabolism. Additionally, it participates in various biochemical reactions, including redox reactions and signal transduction.
Engineered for dietary supplements, α-ketoglutarate supports metabolic balance and energy cycles, complementing formulations by hyaluronic acid suppliers and chitosan manufacturers targeting brain and joint health.
Its biochemical stability enhances antioxidant defenses and insulin sensitivity, boosting formulation efficiency alongside glucosamine chondroitin and inositol in advanced metabolic supplement blends.
Delivering scalable, high-purity ingredient solutions, α-ketoglutarate empowers hyaluronic acid wholesale and bioengineering companies to meet consumer demand for scientifically backed joint, cognitive, and athletic support products.
Alpha-ketoglutarate plays a central role in energy metabolism by supporting the TCA cycle and metabolic balance. Offered by a leading bioengineering company, it targets formulations requiring metabolic and brain health support.
Product Description
Functional Positioning and Target Users for α-Ketoglutarate
α-Ketoglutarate (α-KG) is engineered for formulation in dietary supplements aimed at metabolic enhancement and recovery. Primary users include manufacturers developing joint health supplements, brain energy boosters, and anti-aging products. This intermediate metabolite modulates pathways such as mTOR and AMPK, supporting insulin sensitivity and immune cell metabolism. Its role in energy cycles complements components like glucosamine and sialic acid, aligning with demands for nutraceuticals that enhance cellular function, athletic performance, and cognitive vitality within complex supplement blends.
Technical Features and Molecular Specifics of α-Ketoglutarate
With a molecular formula C5H6O5 and CAS number 328-50-7, α-KG is a pure, biochemically active compound pivotal in the tricarboxylic acid cycle. It supports intracellular antioxidant defenses by aiding glutathione recycling, thus contributing to redox balance. The molecular profile facilitates integration with compounds such as malic acid and pyruvic acid for hybrid formulations. Precise control over purity and molecular weight enables reliable dosing in advanced metabolic health supplements, aligning with industry standards for manufacturing consistency in bioengineering companies focused on quality nutraceutical ingredients.
Industry Applications and Real-World Value of α-Ketoglutarate
Widely applied in metabolic health formulations, α-KG supports joint pain supplements, energy recovery products, and cognitive-enhancement blends. Its compatibility with ingredients like glucosamine chondroitin and gamma-aminobutyric acid enhances product efficacy in nutraceutical manufacturing. This supplement ingredient fits seamlessly into advanced dietary lines aiming to regulate glucose and lipid metabolism, boost immune resilience, and improve athletic recovery. Leveraging α-KG enables formulators to meet both regulatory compliance and consumer demand for scientifically backed, high-performance nutritional products.
Product Advantages
Design and Structural Advantages of α-Ketoglutarate Integration
α-Ketoglutarate’s molecular architecture allows for efficient synergy with bioactive ingredients such as glucosamine supplements and sialic acid, promoting modular formulation design. Its chemical stability facilitates combination with hyaluronic acid and inositol derivatives in multi-ingredient complexes. The compound’s compatibility with carrier systems from bioengineering companies ensures consistent bioavailability. Its role within the α-ketoglutarate dehydrogenase complex further enhances metabolic pathway targeting, enabling formulation flexibility and product scalability for dietary supplement manufacturers focused on structural robustness.
Performance and Usability Benefits for Formulators and End Users
The inclusion of α-KG enhances supplement performance by improving energy metabolism and slowing fatigue, thereby increasing user compliance and satisfaction. Its contribution to antioxidant capacity and insulin sensitivity supports a broader health scope, complementing the effects of glucosamine chondroitin and gamma aminobutyric acid supplements. Formulators benefit from its stability in various dosage forms, including tablets and powders, easing production workflows. This efficient bioactive profile enables product differentiation through scientifically validated metabolic and cognitive support, boosting ROI for wholesale hyaluronic acid suppliers and allied ingredient providers.
Application
α-KG is believed to have anti-aging potential. Studies suggest that it can delay cellular aging by inhibiting the mTOR signaling pathway and activating the AMPK pathway. α-KG exhibits antioxidant properties, scavenging free radicals and reducing oxidative stress-induced cellular damage. It also enhances cellular antioxidant capacity by regulating intracellular levels of reduced glutathione (GSH).
α-KG is widely used in sports nutrition. It improves energy metabolism efficiency, delays exercise-induced fatigue, and promotes post-exercise recovery. Some studies indicate that α-KG supplementation can increase muscle endurance and strength.
α-KG plays a crucial role in regulating glucose and lipid metabolism. By promoting the TCA cycle and enhancing mitochondrial function, it improves insulin sensitivity and lipid metabolism, helping to prevent obesity and type 2 diabetes.
α-KG supports immune cell function by regulating the TCA cycle and amino acid metabolism. It also enhances immune defense by reducing oxidative stress and inflammatory responses.
α-KG has neuroprotective effects. It supports cognitive function and alleviates symptoms of neurodegenerative diseases (e.g., Alzheimer's disease) by providing energy, reducing oxidative stress, and modulating neurotransmitter synthesis.
FAQ
What is the primary role of α-ketoglutarate in cellular metabolism?
α-Ketoglutarate (α-KG) plays a central role in the tricarboxylic acid (TCA) cycle, essential for cellular energy production and nitrogen metabolism. This intermediary supports metabolic balance, which benefits athletic performance, anti-aging mechanisms, and immune cell regulation, making it a vital raw material for nutraceutical formulators.
Can I customize α-KG blends to suit specific supplement formulations?
Yes, GOTHINK Biotech offers customized blend services tailored to your formulation needs, including dosage and form. Leveraging our expertise in glucosamine and hyaluronic acid raw materials, we provide reliable support for targeted formulations like energy, metabolic health, and immune support.
What quality and safety standards does GOTHINK Biotech follow?
Our manufacturing adheres to strict Good Manufacturing Practices (GMP) with thorough analyses to ensure ingredient purity and safety. We maintain full traceability and conduct quality control measures, comparable to standards found in hyaluronic acid manufacturers and chitosan suppliers, ensuring compliance suitable for global markets.
How does GOTHINK Biotech support international logistics and order fulfillment?
GOTHINK Biotech works with over 50 international agents and supplies more than 500 companies worldwide. We provide dependable supply chain management and flexible order handling, enabling seamless delivery of hyaluronic acid wholesale and other raw materials tailored to business requirements.
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